Scientific program

12^th GERLI INTERNATIONAL LIPIDOMICS MEETING, TOULOUSE, FRANCE

Program and invited speakers

To see the time schedule, download the following file: Planning_13_10_16.pdf

SUNDAY OCTOBER 23, 2016

Clémence Isaure Conference Room, (Hôtel d’Assézat): located within the Hôtel d’Assézat, a masterpiece of the Classic Renaissance, in central Toulouse.

Hôtel d'Assézat also contains the Fondation Bemberg, a collection of paintings (from the Renaissance to the 18th century), sculptures, art objects. Sunday opening from 12:30 to 18:00.

17:00 Check-in (Clémence Isaure room)

18:00. KEYNOTE LECTURE (Clémence Isaure room)

Hugues CHAP (France): Endocannabinoids and bacterial infections

    Chairs: Michel Record, Bernard Payrastre & Bertrand Perret

19:00. Welcome reception (Brasserie des Arcades, place du Capitole)

MONDAY OCTOBER 24, 2016

Pierre-Paul Riquet Conference Room, Hôpital Purpan

08:00. Check-in

08:50. Meeting presentation

9:00. MICROBIAL LIPIDS IN HOST-PATHOGEN INTERACTIONS

Chairs: Jérôme Nigou & Frédéric Carrière

09:00. Emilie LAYRE (France): Unbiased lipidomic analysis of Mycobacterium tuberculosis uncovers virulence-associated molecules

09:30. Caroline DEMANGEL (France): Mycobacterial macrolide mycolactone suppresses immune responses by selectively blocking the Sec61 translocon

09:45. Christian SOHLENKAMP (Mexico): Ornithine Lipids in Vibrio cholera

10:00. Souad AMIAR (France): Phosphatidic acid synthesis pathways in Toxoplasma gondii

10:15. Lucie PALOQUE (France): Implication of polyunsaturated fatty acid metabolites derived from Leishmania in parasite/host interaction

10:30. Thierry FONTAINE (France) : Sphingolipids in the human fungal pathogen, Aspergillus fumigatus

11:00. Coffee break & posters

11:45. HOST LIPIDS IN MORPHOGENESIS AND SPREADING OF MICROBES

Chairs: Sylvie Demignot & Erick Dufourc

11:45. Robert V. STAHELIN (USA): Ebola virus and Marburg virus use different modes of lipid gymnastics to assemble and form new viral particles

12:15. Matthieu LEMASSON (France): Knockdown of lysophosphatidylcholine acyltransferase 1 (LPCAT1) increases both the secretion of very-low-density lipoproteins (VLDL) and the infectivity of hepatitis C virus (HCV)

12:30. Sabine CHAPUY-REGAUD (France): Exosomes produced by hepatitis E virus-infected cells spread infection sheltered from neutralizing antibodies

12:45. Jean DUBUISSON (France): Interaction between hepatitis C virus and lipid metabolism during virus entry and assembly

13:15. Lunch & posters

14:45. HOST LIPIDS IN MORPHOGENESIS AND SPREADING OF MICROBES (continues)

Chairs:   Isabelle Dugail & Thierry Levade

14:45. Thierry SOLDATI (Switzerland): Breaking fat! How mycobacteria degrade and re-route host lipids to synthesize triacylglycerols

15:15. Valentina GUERRINI (USA): Lipid composition of lipid droplets in Mycobacterium tuberculosis-infected macrophages

15:30. Jingshu ZHANG (Hong Kong): Lipid droplet associated membrane protein Aup1 facilitates dengue virus release through induction of lipophagy

15:45. Eric MORELLO (France): A lipoxygenase secreted by Pseudomonas aeruginosa increases host production of pro-resolving mediators during lung infection

16:00. Coffee break & posters

16:30. Erich GULBINS (Germany):  Regulation of pulmonary Pseudomonas aeruginosa and Staphylococcus aureus infections by ceramide and sphingosine 

17:00. GERLI PhD THESIS AWARDS  2016

Chairs: Vincent Rioux & Hubert Schaller

17:00. Alicia CONTET (France): Biochemical and biophysical characterizations of two cytidylyltransferases of Plasmopodium falciparum, key enzymes of phospholipids metabolism

17:15. Quang Huy LE (France): Glycoxidized HDL, HDL Enriched With Oxidized Phospholipids and HDL From Diabetic Patients Inhibit Platelet Function

18:30. Guided city tour

TUESDAY OCTOBER 25, 2016 

Pierre-Paul Riquet Conference Room, Hôpital Purpan

8:30. PHOSPHOINOSITIDES AND MICROBE PATHOGENICITY

Chairs: Hugues Chap & Philippe Sansonetti

08:30. Bernard PAYRASTRE (France): Role of phosphoinositides in bacterial infections

09:00. Nicolas VITALE (France): HIV-1 Tat protein palmitoylation is required for the inhibition of neurosecretion, occurring through sequestering of phosphatidylinositol 4,5-bisphosphate by Tat

09:15. Frédéric BOAL (France): PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment

09:30. Ilia BELOTSERKOVSKY (France): Shigella targeting of T lymphocytes requires bacterial adsorption mediated by host plasma membrane glycolipids

09:45. Alassane MBENGUE (USA):  The ER-PI3P vesicle pathway, a crucial mechanism of artemisinin resistance in Plasmodium falciparum malaria

10:15. Coffee break & posters

11:00. FATTY ACIDS AND THERAPEUTIC APPROACHES

Chairs: Agnès Girard-Egrot & Nicolas Vitale

11:00. Charles ROCK (USA): Bacterial Fatty Acid Synthase type II (FAS II) as target for new therapeutic approaches

11:30. Alexandra GRUSS (France): Membrane plasticity of Staphylococcus aureus as a means of antibiotic escape

12:00. Karine GLOUX (France): FASII bypass in clinical Staphylococcus aureus isolates

12:15. Mauricio ROJAS-LOPEZ (Colombia): Fatty acids profile from the exhaled breath condensate differentiates paucibacillary from other TB-patients

12:30. Nicolas CENAC (France): Regulation of visceral pain by eukaryotic and prokaryotic bioactive lipids

13:00. Lunch & posters

14:30. OPEN SESSION

Chairs: Dominique Rainteau & Brigitte Thomasset

14:30. Fong-Fu HSU (USA): Characterization of complex microbial lipids by tandem mass spectrometry and charge switch derivatization

14:45. Stéphane ALEXANDRE (France): Evolution of the lipid composition of the inner membrane of Pseudomonas aeruginosa cells grown in pellicle at the air-water interface

15:00. Mehmet Nail NASIR (Belgium): The lipid fraction of plant plasma membrane has a key role during the immune related defense response by the natural lipopeptide surfactin

15:15. Annette DRAEGER (Switzerland): Liposomal neutralization of bacterial toxins

15:30. Tributes to Philippe Devaux and Paul Grimaldi by Erick Dufourc and Isabelle Niot

15:45. Coffee break & posters

15:45. Bus departure to Montauban

SOCIAL PROGRAM IN MONTAUBAN (Toulouse vicinity)

16:30. Visit of Musée Ingres  

18:30. Gala dinner (Hôtel-Abbaye des Capucins). Concert with the Brass Band “Aéris” (more informations on the web page "social program")

22:00. Bus departure to Toulouse (arrival at 22:45)

WEDNESDAY OCTOBER 26, 2016 

Pierre-Paul Riquet Conference Room, Hôpital Purpan

8:30. HOST ANTIMICROBIAL STRATEGIES

Chairs: Lhousseine Touqui & Gérard Lambeau

08:30. Edward DENNIS (USA): Lipidomics highlight infection and inflammation progression

09:00. Camille ROBERT (France): Evaluation of the therapeutic potential of an anti-inflammatory mannodendrimer in a mouse model of Francisella tularensis infection

09:15. Graham BROGDEN (Germany): Effect of lipid alterations on cathelicidin-mediated formation of extracellular DNA traps in different immune cells

09:30. Mélanie DACHEUX (France): On the role of human group IIA phospholipase A2 in malaria: from in vitro to in vivo mouse studies

09:45. Jerrold P. WEISS (USA): Role and regulation of antibacterial activity of mammalian secretory phospholipases A2

10:15. Coffee break & posters

11:00. Agnes COSTE (France): LRH-1 mediates anti-inflammatory and anti-fungal phenotype of IL13-activated macrophages through the PPARγ ligand synthesis 

11:30. LIPIDS AND THE MICROBIOTA

Chairs: Vincent Rioux & Xavier Collet

11:30. Anne FERLAY (France) : Production of trans and conjugated fatty acids in dairy ruminants and their putative effects on human health

12:00. Eric LE BALC'H (France): A new N-acyl-homoserine lactone identified in gut ecosystem is associated with normobiosis and exerts an anti-inflammatory effect

12:15. Isabelle DUGAIL (France): Lipidomic blood profiles in obesity associate with gut microbiota richness

12:30. Julien PUJO (France): Characterization of bioactive lipids produced by a pathogenic Escherichia coli bacteria: role in visceral hypersensitivity

12:45. Lunch & posters

14:30. Nathalie DELZENNE (Belgium): Role of the gut microbiota in the production of fatty acid metabolites : which consequence for host health?

15:00. MICROBE LIPID IMAGING

Chairs: Olivier Laprévote & Justine Bertrand-Michel

15:00. Brendan PRIDEAUX (USA) :  Spatial distribution of inflammatory lipids by MALDI imaging in tuberculosis pathology

15.30: Landry BLANC (USA): Visualization of Mycobacterial biomarkers by MALDI MS Imaging

15:45. Alain BRUNELLE (France) : Mass spectrometry imaging of the chemical communication between endophytic fungus Paraconiothyrium variabile and bacterium Bacillus subtilis

16:15. Coffee break & posters 

16:30. KEYNOTE CONCLUDING LECTURE

Chair: Hugues Chap

16:30. Philippe SANSONETTI (France):  Fat, gut and microbes: a greasy "ménage à trois"

17:00. Presentation of the GERLI meeting 2017 in Dijon

17:15 Departure